IBIDS_Database

Inhibitors of cytochrome P-450 augment fever induced by interleukin-1 beta.
      

Record Detail

Return to previous page
Save:
Title: Inhibitors of cytochrome P-450 augment fever induced by interleukin-1 beta.
Author: Nakashima, T : Harada, Y : Miyata, S : Kiyohara, T
Citation: Am-J-Physiol. 1996 Nov; 271(5 Pt 2): R1274-9
Abstract: Metabolites of cytochrome P-450 are produced in cells when arachidonic acid cascade is activated. Fever genesis depends largely on the cyclooxygenase branch of arachidonic acid cascade, which is caused by many stimuli, such as interleukin (IL)-1, IL-6, and interferon-alpha. To assess the significance of cytochrome P-450 branch in fever, murine recombinant IL-1 beta was bilaterally microinjected (1 ng/microliter) into the medial preoptic area and anterior hypothalamus in conscious rats treated 60 min previously with or without the cytochrome P-450 inhibitor econazole (15 mg/kg im). The IL-1 beta-induced rise in colonic temperature was enhanced after the plateau phase of fever (from 240 min after IL-1 beta) in econazole-pretreated rats (P less than 0.001). Another cytochrome P-450 inhibitor, clotrimazole (15 mg/kg im), also enhanced IL-1 beta-induced fever from 160 min after IL-1 beta injection (P less than 0.001). Econazole also enhanced the fever when it was given 120 min before injection of IL-1 beta (P less than 0.001). The cytochrome P-450 inhibitor, however, did not affect the fever when given 10 min after IL-1 beta (P = 0.95). Econazole and clotrimazole did not alter normal body temperature (P = 0.65 and 0.73, respectively). The results suggest that the metabolite(s) of cytochrome P-450 affect the falling phase after the plateau phase of fever and act as putative endogenous antipyretic(s).
Review References: None
Notes: Copyright American Physiological Society. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic journal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page.
Language: English
Publication Type: Journal-Article
Keywords: Antifungal Agents pharmacology : Clotrimazole pharmacology : Cytochrome P 450 antagonists and inhibitors : Econazole pharmacology : Fever chemically induced : Fever physiopathology : Interleukin 1
URL: http://ajpcon.physiology.org/