Hyperglycemia may determine fibrinopeptide A plasma level increase in humans.

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Title:	Hyperglycemia may determine fibrinopeptide A plasma level increase in humans.
Author:	Ceriello, A : Giugliano, D : Quatraro, A : Dello Russo, P : Marchi, E : Torella, R
Citation:	Metabolism. 1989 Dec; 38(12): 1162-3
Abstract:	The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Journal-Article
Keywords:	Fibrinogen analysis : Fibrinopeptide A analysis : Hyperglycemia metabolism
URL:	http://www.wbsaunders.com/catalog/wbs-prod.pl?0026-0495