Buprenorphine pharmacokinetics: relative bioavailability of sublingual tablet and liquid formulations.

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Title:	Buprenorphine pharmacokinetics: relative bioavailability of sublingual tablet and liquid formulations.
Author:	Nath, R P : Upton, R A : Everhart, E T : Cheung, P : Shwonek, P : Jones, R T : Mendelson, J E
Citation:	J-Clin-Pharmacol. 1999 Jun; 39(6): 619-23
Abstract:	Buprenorphine is an effective new treatment for opiate dependence. This study compared the bioavailability of buprenorphine from a tablet to that from a reference solution. Six men experienced with, but not dependent on, opiates (DSM-III-R) were each administered 7.7 mg of buprenorphine in liquid form and 8 mg in tablet form 1 week apart in a balanced crossover design. Plasma levels were measured by electron capture capillary gas chromatography (GC), and concentration-time curves were constructed. Pharmacokinetic data were analyzed by analysis of variance. The bioavailability from the tablet was approximately 50% that from the liquid and was not affected by saliva pH. Lower bioavailability from the tablet may be due to slow dissolution.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Clinical-Trial; Journal-Article
Keywords:	Analgesics, Opioid pharmacokinetics : Buprenorphine pharmacokinetics
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