Inhibition of the infectivity of influenza virus by tea polyphenols.

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Title:	Inhibition of the infectivity of influenza virus by tea polyphenols.
Author:	Nakayama, M : Suzuki, K : Toda, M : Okubo, S : Hara, Y : Shimamura, T
Citation:	Antiviral-Res. 1993 Aug; 21(4): 289-99
Abstract:	(-)Epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) (1-10 microM) inhibited the infectivity of both influenza A virus and influenza B virus in Madin-Darby canine kidney (MDCK) cells in vitro. Study by electron microscope revealed that EGCg and TF3 (1 mM) agglutinated influenza viruses as well as did antibody, and that they prevented the viruses from adsorbing to MDCK cells. EGCg and TF3 more weakly inhibited adsorption of the viruses to MDCK cells. EGCg and TF3 (1-16 microM) also inhibited haemagglutination by influenza viruses. These findings suggest that tea polyphenols bind to the haemagglutinin of influenza virus, inhibit its adsorption to MDCK cells, and thus block its infectivity.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Journal-Article
Keywords:	Antiviral Agents pharmacology : Benzocycloheptenes pharmacology : Catechin analogs and derivatives : Gallic Acid analogs and derivatives : Influenza A Virus drug effects : Influenza A Virus pathogenicity : Influenza B Virus drug effects : Influenza B Virus pathogenicity : Plant Extracts pharmacology
URL:	http://www.elsevier.nl/inca/publications/store/5/2/1/8/5/2/index.htt