Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.

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Title:	Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.
Author:	Booth, S L : Charnley, J M : Sadowski, J A : Saltzman, E : Bovill, E G : Cushman, M
Citation:	Thromb-Haemost. 1997 Mar; 77(3): 504-9
Abstract:	Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1 equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.
Review References:	63 refs.
Notes:	None
Language:	English
Publication Type:	Journal-Article; Review; Review-Literature
Keywords:	Anticoagulants therapeutic use : Coumarins therapeutic use : Diet : Phytonadione pharmacology
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