[Effect and mechanism of rhubarb on fibrinolysis in secondary damagedcentral nerve system of rats with acute hemorrhagic stroke]

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Title:	[Effect and mechanism of rhubarb on fibrinolysis in secondary damagedcentral nerve system of rats with acute hemorrhagic stroke]
Author:	Cai,-D-F; Dai,-W; Chen,-Y-P; Wen,-M; Dai,-H-L
Citation:	Zhongguo-Zhong-Xi-Yi-Jie-He-Za-Zhi. 2005 Jan; 25(1): 38-41
Abstract:	OBJECTIVE: To observe the effect of rhubarb in treating secondary damage ofcentral nerve system (CNS) in rats with acute hemorrhagic stroke (AHS) and toexplore the possible mechanism. METHODS: The rat's AHS model was established byautologous blood injection, the effect of rhubarb on the secondary damage ofCNS, plasminogen (PLG) in brain and tissue type plasminogen activator (t-PA)were observed. RESULTS: (1) The nerve function deficit signs reappeared in about70% model rats 4 - 6 days after modeling and reached the peak at day 6 - 8,scored as 1.63 +/- 0.72 on day 4 and as 2.32 +/- 1.12 on day 7; (2) Rhubarbcould effectively improve the secondary nerve function damage, with the nervedeficit scores kept to 1.24 +/- 0.19 from day 4 on, and no sign of secondary CNSdamage was shown. The nerve deficit score was 1.22 +/- 0.15 on day 7 in therhubarb treated group, showing significant difference as compared with that inthe model group (Pless than 0.05); (3) The specific amplified products of t-PA mRNA onday 3 and that of PLG mRNA on day 7 in CNS of model group were significantlyhigher than those in the sham operated group and the rhubarb treated group.
Review References:	None
Notes:	None
Language:	Chinese; Non-English
Publication Type:	Journal-Article
Keywords:	Drugs,-Chinese-Herbal-pharmacology; Intracranial-Hemorrhages-blood;Intracranial-Hemorrhages-pathology; Intracranial-Hemorrhages-physiopathology;Plasminogen-biosynthesis; Plasminogen-Activator-Inhibitor-1-biosynthesis;*Rheum-chemistry
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