Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia.

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Title:	Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia.
Author:	Su,-B-N; Chai,-H; Mi,-Q; Riswan,-S; Kardono,-L-B; Afriastini,-J-J; Santarsiero,-B-D; Mesecar,-A-D; Farnsworth,-N-R; Cordell,-G-A; Swanson,-S-M; Kinghorn,-A-D
Citation:	Bioorg-Med-Chem. 2006 Feb 15; 14(4): 960-72
Abstract:	Activity-guided fractionation of a CHCl(3)-soluble partition of the MeOH extract of the bark of Aglaia crassinervia collected in Indonesia led to the isolation of three new glabretal-type triterpenoids, aglaiaglabretols A-C (1-3), as well as nine known compounds, 3-epi-cabraleahydroxylactone (4), cabraleahydroxylactone (5), rocaglaol (6), 2beta,3beta-dihydroxy-5alpha-pregn-17(20)-(E)-16-one, scopoletin, and mixtures of cabraleadiol and epicotillol and of beta-sitosterol and stigmasterol. The structures of compounds 1-3 were determined on the basis of spectroscopic and chemical methods. The structure of aglaiaglabretol A (1) was confirmed by single-crystal X-ray analysis, and the absolute stereochemistry of this isolate was established by the Mosher ester method. The cytotoxic activity of all isolates and several chemical transformation products obtained in the present study was evaluated. The known cyclopenta[b]benzofuran, rocaglaol (6), was found to be significantly active and comparable in potency to the positive controls, paclitaxel and camptothecin. Aglaiaglabretol B (2) was further tested in an in vivo hollow fiber model.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Journal-Article
Keywords:	Aglaia-chemistry; Plant-Bark-chemistry; Plant-Extracts-isolation-and-purification; Plant-Extracts-toxicity
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