Chemoprevention of OH-BBN-induced bladder cancer in mice by piroxicam.

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Title:	Chemoprevention of OH-BBN-induced bladder cancer in mice by piroxicam.
Author:	Moon, R C : Kelloff, G J : Detrisac, C J : Steele, V E : Thomas, C F : Sigman, C C
Citation:	Carcinogenesis. 1993 Jul; 14(7): 1487-9
Abstract:	Piroxicam inhibited induction of transitional cell carcinoma in mouse urinary bladder by N-butyl-N-(4-hydroxybutyl)-nitrosamine. At 15 mg piroxicam/kg diet, tumor incidence was reduced 82% (P less than 0.0001) compared with carcinogen controls. At 30 mg piroxicam/kg diet, tumor incidence was reduced 70% (P less than 0.001). Results at the higher dose level suggested that piroxicam also may have inhibited invasion slightly. Combination treatment with 2-difluoromethyl-ornithine (DFMO) or all-trans-N-(4-hydroxyphenyl)retinamide (4-HPR) or both agents did not improve the chemopreventive potential of piroxicam. However, the three-agent combination of 30 mg piroxicam/kg, 1200 mg DFMO/kg and 313 mg 4-HPR/kg diet was highly effective. Tumor incidence was reduced 91% (P less than 0.0001) compared with carcinogen controls. Unfortunately, the high efficacy was somewhat compromised by a significant decrease in survival and body weight gain in mice receiving the combination of agents compared with the carcinogen control.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Journal-Article
Keywords:	Bladder Neoplasms prevention and control : Butylhydroxybutylnitrosamine : Carcinoma, Transitional Cell prevention and control : Piroxicam pharmacology
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